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Griffith's experiment
Griffith's Experiment( 1928) Note: For the convenience of students we have compiled the experiment in to a flow chart, how ever it is advised to refer textbooks for details. Found different types of pneumo coccal strains which can cause pneumonia, in infected mice
(1) Infected type 1 encapsulated pneumococci in some mice
Result ===> All mice died due to Pneumonia
(2) Infected type 2 capsule less pneumococci (forming rough colonies) in some mice
Result ====> All mice survived
(3) Injected heat killed type 1 pneumo cocci with smooth colonies in some mice
result ====> All mice survived
(4) Injected heat killed type 1 pneumo cocci with live type 2 capsule less pneumo cocci in same mice
Mice dies due to pneumonia
(5) Bacterial cells isolated from dead mice
Found type 2, 1 & 3 encapsulated pneumococci forming smoth colonies
Conclusion: Dead type 1 cells provided something to live, non capsulated type 2 cells that transformed them into an encapsulated type 1, 2 & 3 forms.
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