Contribution of Avery, mcleod, mccarty

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Contribution of Avery, Mcleod & Mccarty(1944)

Note: For the convenience of the students we have compiled the experiment in form of a flowchart, however it is advised to refer text books for details.

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They isolated the encapsulated type 2 pneumococci from infected mice & killed it

Rapid freezing & thawing

Heating the disrupted cells

Centrifuged the suspension

Filtered the supernatant through porcelain filters

Supernatant had the same transforming ability as that of original heat killed cells